This research based on Accenture’s ongoing study of persons with disabilities in the workplace, and advances in “human + machine” work, shows that Artificial Intelligence (AI)—when developed and used responsibly and ethically—has the potential to facilitate the entire employment journey for persons with disabilities. It can help organizations identify candidates (and vice versa). It can enable engagement at work. And it can drive a culture of confidence in this underutilized segment of the workforce while supporting advancement within organizations. The study encourages those committed to developing ethical AI to use the R(AI)S guiding principles (Responsible, Accessible, Inclusive, Secure) to inform decision-making about using AI to improve inclusion. This study has been created in collaboration with Disability:IN and the American Association of People with Disabilities (AAPD).